Bone Pastes
new generation visco-modulated bone pastes

orthopaedics

Activabone®

The new generation of bone pastes

Packed with technology

The line of Activabone® bone pastes stems from a unique technological combination. The equine origin bone substitutes obtained through the exclusive Zymo-Teck® enzymatic process are now associated to Exur®, the innovative polymer carrier with modulated viscosity developed by Bioteck R&D.

Bone pastes represent a valid alternative to conventional bone grafts, however the carriers often feature rheological properties that are unsuited to assuring good handling or withstanding leaching during grafting in a bloody environment. However, the Activabone® line features an extraordinary balance of rheological and biological properties.

Properties & Performances

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DBM Gel CLX Gel
Injectable
Mouldable
CS Mix Putty
Osteopromotion
Osteoconduction
Withstand leaching
Density
Injectable
Mouldable

The technology

Zymo-Teck® Process

The use of enzymes, without using potentially harmful chemicals, results in perfect cleaning of the bone tissue while retaining its physical and morphological features, also preserving the extracellular bone matrix in its native conformation.

Exur®

The innovative carrier combines synthetic polymers with ancillary quantities of ascorbic acid having a visco-modulating function to obtain bone substitutes having controlled biological properties, texture, malleability and adhesiveness, so as to perfectly adapt to the geometry of bone defects of any size or shape.

Mineralized bone

  • Physiological osteoclastic adhesiveness: natural remodeling
  • Presence of collagen in native conformation: greater formation of new bone tissue
  • Optimal osteoconduction

Demineralized bone matrix (DBM)

  • Obtained through a demineralization process of cortical bone extracellular matrix
  • Contains all the elements naturally found in bone matrix and makes them immediately available to the body
  • Regeneration-promoting effect known in the literature since the 1970s

Hydrogel polimerico

  • Optimal graft hydration
  • Provides the ideal environment for cellular proliferation

Vitamin C

  • Limits or prevents intra- and intermolecular reorganization of polymer chains
  • Modulates viscosity providing superior rheological properties

Surgical Advantages

Leaching withstand ability and easier handling - Bone pastes based on first generation carriers (standard), often feature rheological properties unsuited to assure good handling or to withstand leaching during grafting in a bloody environment.

Perfect adaptability: a graft for any defect. By suitably modifying the dose of Vitamin C (visco-modulating), it is possible to obtain extremely versatile and functional bone substitutes, having specific biological properties, texture, malleability and adhesiveness, such as to adapt perfectly to the specific geometry of the bone defects of any dimension or shape.

Optimal dissolution

Persists at the grafting site for the time required for tissue regeneration to occur.

Enhanced osteopromotion

Thanks to the optimal proliferation of cells within the three-dimensional structure of the polymeric carrier and, in some formats, strongly implemented by the presence of DBM.

Perfect adaptability

The wide range of available visco-elasticity makes it easy to find the right product for any type of defect.

Clinical Advantages

Optimal regeneration - The total remodeling biomaterial is combined with a polymer carrier that further enhances its regenerative power: while maintaining stability and spaces, it actively stimulates the formation of new bone tissue.

Formation of bone

1 - Formation of immature (fibrous) bone tissue due to use of quickly dissolving bone pastes.

Formation of bone

2 - Perfectly regenerated bone tissue thanks to the use of Activabone® pastes. Notice the presence of the already perfectly developed marrow component.

Products

Activabone® DBM CEL

Activabone® DBM GEL

Composition: Demineralized bone matrix (DBM), Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: osteo-promoter to be mixed with grafts for filling bone defects, including non contained ones. Applied on the surfaces of bone blocks and wedges to accelerate osseointegration in additive osteotomy and arthrodesis procedures.

Advantages: it combines the osteo-promoting effect of DBM with the specific rheological properties of the carrier.

ACT-GEL010 - 1 syringe - 1.0 cc
ACT-GEL020 - 1 syringe - 2.0 cc
ACT-GEL050 - 1 syringe - 5.0 cc
ACT-GEL0100 - 1 syringe - 10.0 cc

Activabone® CLX CEL

Activabone® CLX GEL

Composition: Bone powder, cancellous granules Ø 0.5-1 mm, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: carrier to improve the texture of bone grafts and cell concentrates.

Advantages: it promotes better graft management and maintenance on site.

ACT-CLX020 - Bone Powder Gel - 1 syringe - 2.0 cc
ACT-CLX050 - Bone Powder Gel - 1 syringe - 5.0 cc
ACT-CLX0100 - Bone Powder Gel - 1 syringe - 10.0 cc

Activabone® INJECTABLE PASTE

Activabone® INJECTABLE PASTE

Composition: demineralized bone matrix (DBM), bone powder, type I collagen, Exur® (low molecular weight carrier (LMW), Vitamin C).

Applications: injectable paste osteo-promoter for filling contained bone defects or in percutaneous treatment of pseudarthrosis and consolidation delays.

Advantages: it combines the osteo-promoting effect of DBM with the specific rheological properties of the carrier, high fluidity (easy to extrude), does not require hydration (shortening of surgical times), complete remodeling.

AACT-INJ010 - DBM Injectable Paste - 1 syringe - 2.0 cc
AACT-INJ020 - DBM Injectable Paste - 1 syringe - 1.0 cc
AACT-INJ050 - DBM Injectable Paste - 1 syringe - 5.0 cc
AACT-INJ0100 - DBM Injectable Paste - 1 syringe - 10.0 cc

Activabone® Mouldable Paste

Activabone® Mouldable Paste

Composition: Demineralized bone matrix (DBM), bone powder, cortical and cancellous granules Ø 0.5-1 mm, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: all bone regeneration procedures, in either contained or non contained defects. Pseudarthrosis, consolidation delays, arthrodesis.

Advantages: the osteo-promoting effect of DBM and the specific rheological properties of the carrier are combined with a high osteoconductive effect given by the presence of bone granules. Excellent ease of handling (moldable), does not require hydration (shortening of surgical times), complete remodeling.

ACT-MLD010 - DBM Mouldable Paste - 1 syringe - 2.0 cc
ACT-MLD020 - DBM Mouldable Paste - 1 syringe - 1.0 cc
ACT-MLD050 - DBM Mouldable Paste - 1 syringe - 5.0 cc
ACT-MLD0100 - DBM Mouldable Paste - 1 syringe - 10.0 cc

Activabone® Crunch

Activabone® Crunch

Composition: Bone powder, cancellous granules Ø 0.5-1 mm, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: filling either contained or non contained bone defects, graft in periprosthetic defects.

Advantages: high ease of handling combined with ideal osteoconductive effect. Does not require hydration (shortening of surgical times), complete remodeling.

ACT-CRU010 - Collagen Chips Crunch - 1 syringe - 1.0 cc
ACT-CRU020 - Collagen Chips Crunch - 1 syringe - 2.0 cc
ACT-CRU050 - Collagen Chips Crunch - 1 syringe - 5.0 cc
ACT-CRU0100 - Collagen Chips Crunch - 1 syringe - 10.0 cc

Activabone® PATCH

Activabone® Patch

Composition: demineralized bone matrix (DBM), bone powder, Ø 0.5-2 mm cancellous chips, Ø 0.5-1 mm cortical chips, type I collagen, Exur® (high molecular weight carrier (HMW), Vitamin C).

Applications: reconstruction of acetabular and periprosthetic defects in hip and knee arthroplasty.

Advantages: graft ready for use, easy to mold extemporaneously in the operating room with scissors or knife. It assures excellent contact between prosthetic component and bone graft, preventing the risk of bone granules in the joint. Osteo-promoting effect given by DBM. Complete remodeling.

ACT-PCH030 - Pre-Shaped DBM Patch - 1 pc - Ø30 x 6 mm
ACT-PCH070 - Pre-Shaped DBM Patch - 1 pc - Ø70 x 6 mm

Activabone® Strip

Activabone® Strip

Composition: demineralized bone matrix (DBM), bone powder, Ø 0.5-2 mm cancellous chips, Ø 0.5-1 mm cortical chips, type I collagen, Exur® (high molecular weight carrier (HMW), Vitamin C).

Applications: posterolateral fusions and arthrodesis of small joints.Applications: posterolateral fusions and arthrodesis of small joints.

Advantages: graft ready for use, easy to mold extemporaneously in the operating room with scissors or knife. It assures excellent contact between prosthetic component and bone graft, preventing the risk of bone granules in the joint. Osteo-promoting effect given by DBM. Complete remodeling.

ACT-STR020 - Pre-Shaped DBM Strip - 1 pc - 10 x 40 x 6 mm
ACT-STR510 - Pre-Shaped DBM Strip - 1 pc - 15 x 50 x 6 mm
ACT-STR520 - Pre-Shaped DBM Strip - 1 pc - 15 x 100 x 6 mm

Activabone® Putty

Activabone® Putty

Composition: Bone powder, cancellous granules Ø 0.5-1 mm, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: bone graft in containing defects (Post-extractive socket, cavities left by bone cysts).

Advantages: excellent osteoconductive effect (bone granules, bone powder), osteopromoting effect given by the 3D carrier structure and by the preserved bone collagen, can be used dry or after hydration. When hydrated it becomes moldable. Total remodeling.

ACT-PTY020 - Collagen Granules Dry Paste - 1 pc - 2.0 cc
AACT-PTY030 - Collagen Granules Dry Paste - 1 pc - 3.0 cc
AACT-PTY050 - Collagen Granules Dry Paste - 1 pc - 5.0 cc
AACT-PTY100 - Collagen Granules Dry Paste - 1 pc - 10.0 cc

For more information

Get in touch with Bioteck to learn more about Activabone . Fill out the form with your details and we will contact you directly.