Bone Pastes
new generation visco-modulated bone pastes

dental surgery

Activabone®

The new generation of bone pastes

Packed with technology

The line of Activabone® bone pastes stems from a unique technological combination. The equine origin bone substitutes obtained through the exclusive Zymo-Teck® enzymatic process are now associated to Exur®, the innovative polymer carrier with modulated viscosity developed by Bioteck R&D.

Bone pastes represent a valid alternative to conventional bone grafts, however the carriers often feature rheological properties that are unsuited to assuring good handling or withstanding leaching during grafting in a bloody environment. However, the Activabone® line features an extraordinary balance of rheological and biological properties.

Properties & Performances

I° generation ACTIVABONE
Handling and mouldability
Homogeneous mixture
Withstand leaching in a bloody environment
Osteopromotional effect

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DBM Gel CLX Gel
Injectable
Mouldable
CS Mix Putty
Osteopromotion
Osteoconduction
Withstand leaching
Density
Injectable
Mouldable

The technology

Zymo-Teck® Process

The use of enzymes, without using potentially harmful chemicals, results in perfect cleaning of the bone tissue while retaining its physical and morphological features, also preserving the extracellular bone matrix in its native conformation.

Exur®

The innovative carrier combines synthetic polymers with ancillary quantities of ascorbic acid having a visco-modulating function to obtain bone substitutes having controlled biological properties, texture, malleability and adhesiveness, so as to perfectly adapt to the geometry of bone defects of any size or shape.

Mineralized bone

  • Physiological osteoclastic adhesiveness: natural remodeling
  • Presence of collagen in native conformation: greater formation of new bone tissue
  • Optimal osteoconduction

Demineralized bone matrix (DBM)

  • Obtained through a demineralization process of cortical bone extracellular matrix
  • Contains all the elements naturally found in bone matrix and makes them immediately available to the body
  • Regeneration-promoting effect known in the literature since the 1970s

Hydrogel

  • Optimal graft hydration
  • Provides the ideal environment for cellular proliferation

Vitamin C

  • Limits or prevents intra- and intermolecular reorganization of polymer chains
  • Modulates viscosity providing superior rheological properties

Surgical Advantages

Leaching withstand ability and easier handling - Bone pastes based on first generation carriers (standard), often feature rheological properties unsuited to assure good handling or to withstand leaching during grafting in a bloody environment.

Perfect adaptability: a graft for any defect. By suitably modifying the dose of Vitamin C (visco-modulating), it is possible to obtain extremely versatile and functional bone substitutes, having specific biological properties, texture, malleability and adhesiveness, such as to adapt perfectly to the specific geometry of the bone defects of any dimension or shape.

Optimal dissolution

Persists at the grafting site for the time required for tissue regeneration to occur.

Enhanced osteopromotion

Thanks to the optimal proliferation of cells within the three-dimensional structure of the polymeric carrier and, in some formats, strongly implemented by the presence of DBM.

Perfect adaptability

The wide range of available visco-elasticity makes it easy to find the right product for any type of defect.

Clinical Advantages

Optimal regeneration - The total remodeling biomaterial is combined with a polymer carrier that further enhances its regenerative power: while maintaining stability and spaces, it actively stimulates the formation of new bone tissue.

Formation of bone

1 - Formation of immature (fibrous) bone tissue due to use of quickly dissolving bone pastes.

Formation of bone

2 - Perfectly regenerated bone tissue thanks to the use of Activabone® pastes. Notice the presence of the already perfectly developed marrow component.

Products

Activabone® CLX GEL

Activabone® DBM GEL

Composition: Demineralized bone matrix (DBM), Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: liquid osteopromoter, it may be mixed with granular grafts or spread on the surface of block grafts.

Advantages: liquid form, combines the osteopromoting effect of DBM with that of the carrier.

ACT-GEL005 Activabone DBM gel 1 syringe 0.5 cc

Activabone® CLX GEL

Activabone® CLX GEL

Composition: Bone powder, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: to replace a membrane for protecting bone defects in small periodontal defects (short protection time), as bone graft in minimal containing defects.

Advantages: mild osteoconductive effect (bone powder), osteopromoting effect given by the 3D carrier structure, high fluidity (easy to extrude), does not require hydration (shorter surgery time), total remodeling.

ACT-CLX010 Activabone CLX gel 1 syringe 1.0 cc

Activabone® Injectable paste

Activabone® Injectable paste

Composition: Demineralized bone matrix (DBM), bone powder, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: osteopromoter in injectable paste also usable as bone graft in sinus lift through crestal approach and in small containing defects.

Advantages: moderate osteoconductive effect (bone powder, DBM), it combines the osteopromoting effect given by the DBM to that of the carrier, high fluidity (easy to extrude), does not require hydration (shorter surgery time), total remodeling.

ACT-INJ005 Activabone DBM injectable paste 1 syringe 0.5 cc
ACT-INJ010 Activabone DBM injectable paste 1 syringe 0.5 cc

Activabone® Mouldable Paste

Activabone® Mouldable Paste

Composition: Demineralized bone matrix (DBM), bone powder, cortical and cancellous granules Ø 0.5-1 mm, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: all bone regeneration procedures.

Advantages: good osteoconductive effect (bone granules, bone powder, DBM), it combines the osteopromoting effect given by the DBM to that of the carrier and preserved bone collagen, excellent handling (moldable), does not require hydration (shorter surgery time), total remodeling.

ACT-MLD005 Activabone DBM mouldable paste 1 syringe 0.5 cc
ACT-MLD010 Activabone DBM mouldable paste 1 syringe 1.0 cc

Activabone® CS MIX

Activabone® CS Mix

Composition: Bone powder, cortical and cancellous granules Ø 0.5-1 mm, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: all bone regeneration procedures.

Advantages: excellent osteoconductive effect (bone granules, bone powder), osteopromoting effect given by the 3D carrier structure and by the preserved bone collagen, does not require hydration (shorter surgery time), total remodeling.

AACT-CMX025 Activabone Mix granules in syringe 1 syringe t0.25 cc
ACT-CMX050 Activabone Mix granules in syringe 1 syringe 0.5 cc

Activabone® Putty

Activabone® Putty");?>

Composition: Bone powder, cancellous granules Ø 0.5-1 mm, type I collagen, Exur® (low molecular weight carrier - LMW, Vitamin C).

Applications: bone graft in containing defects (Post-extractive socket, cavities left by bone cysts).

Advantages: excellent osteoconductive effect (bone granules, bone powder), osteopromoting effect given by the 3D carrier structure and by the preserved bone collagen, can be used dry or after hydration. When hydrated it becomes moldable. Total remodeling.

ACT-PTY005 Activabone putty 1 piece 0.5 cc
ACT-PTY010 Activabone putty 1 piece 1.0 cc

For more information

Get in touch with Bioteck to learn more about Activabone . Fill out the form with your details and we will contact you directly.